Publications

Articles

-Tremblay, G.A. 2017. A Narrative for Bioanalytical Method Development. Editorial accepted for publication in the Feb. issue of Bioanalysis. Published online: 13 January 2017. doi:10.4155/bio-2016-0287.

-Tremblay, G.A., Khalafaghian, G., Legault, J., Nielsen, P. and Bartlett, A.J. 2011. Specific determination of oligonucleotide therapeutics with the dual ligation hybridization assay. Bioanalysis. 3 (5): 499-508.

-Tremblay, G.A. and Oldfield, P.R. 2009. Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues. Bioanalysis. 1 (3): 595-609.

-Tremblay, G.A. 2007. Historical statistics support a hypothesis linking tuberculosis and air pollution caused by coal. International Journal of Tuberculosis and Lung Disease. 11 (7): 722-33.

-Tremblay, G.A., Richard, S. 2006. mRNAs Associated with the Sam68 RNA Binding Protein. RNA Biology. 3 (2): 90-93.

-Richard, S., Torabi, N., Valverde-Franco, G., Tremblay, G.A., Chen, T., Vogel, G., Morel, M., Cleroux, P., Komarova, S., Tremblay, M.L., Li, W., Gao, Y.J. and Henderson, J. 2005. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PloS Genetics. 1 (6): 676-688.

-Brukner, I., Tremblay, G.A., Paquin B. 2002. Generation of amplifiable genome-specific oligonucleotide probes/libraries. Biotechniques. 33 (4):874-6.

-Brukner, I., Tremblay, G.A. 2000. Cellular proteins prevent antisense phosphorothioate oligonucleotide (SdT18) to target sense RNA (rA18): development of a new in vitro assay. Biochemistry. 39 (37): 11463-6.

-Beauséjour C.M., Tremblay G., Momparler R.L. 2000. Potential of ribozymes against deoxycytidine kinase to confer drug resistance to cytosine nucleoside analogs. Biochem. Biophys. Res. Commun. 278 (3): 569-75.

Scientific Talks

-Presenting at the Current Topics on the Analysis of Oligonucleotides workshop: PCR and ELISA: like assays for bioanalytics. EuroTIDES (Oligonucleotides and Peptides) Meeting, November 16-19th 2010, Barcelona, Spain.

-Chairing and Presenting at a workshop on Bioanalytical Methods for the Determination of Therapeutic Oligonucleotides: Specific Determination of Oligonucleotide Therapeutics Using a Dual Ligation Hybridization Assay and Advances with qPCR on Dried Blood Spots. TIDES (Oligonucleotides and Peptides) Meeting, April 24-28th 2010, Boston, MA. Posters / Meetings

-Annual meeting AAPS 2011 Poster: Challenges in preclinical bioanalytical method development of the deoxypyridinoline (DPD) bone resorption biomarker in rat urine, October 2011, Washington DC.

-Annual meeting DIA 2010 Poster: Specific Determination of Oligonucleotide Therapeutics by Dual Ligation Hybridization Assay, June 2010, Washington, DC.

-Annual meeting AAPS 2009 Poster: A Parent-Specific Hybridization Assay for Quantifying Therapeutic Oligonucleotides and siRNA in Biological Samples, November 2009, Los Angeles, CA.

-Annual meeting AAPS 2008 Poster: A Simplified Tissue Extraction Method and Plasma Bioanalysis of a Liposome-Encapsulated Immunostimulatory Oligonucleotide, mODN 6303: Qualification and Pharmacokinetic Profiles in Sprague Dawley Rats, November 2008, Atlanta, GA.

-Attendance: Annual meeting of the American Society of Virology (ASV), June 2006, Penn State University, PA.

Patents

-Guy A. Tremblay. April 2010 and November 2009. Dual Ligation methods for detecting oligonucleotides. USPTO Pat. Pend. US 61/327,245 and 61/258,046.

-Ivan Brukner, Guy Tremblay, Bruno Paquin. January 2000. Process for the generation of oligonucleotide libraries (OLs) representative of genomes or expressed mRNAs (cDNA) and uses thereof. WO 00/43538.

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